Imidazolidinedione derivatives
AssigneeAutifony Therapeutics Limited
InventorsGiuseppe Alvaro, Anne Decor, Stefano Fontana, Dieter Hamprecht, Charles Large, Agostino Marasco
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Abstract
The invention provides a compound of formula (Ia), and pharmaceutically acceptable salts thereof. The invention also provides use of the compounds or salts as modulators of Kv3.1 and/or Kv3.2, and in the treatment of diseases or disorders where a modulator of Kv3.1 and/or Kv3.2 is required, such as depression and mood disorders, hearing disorders, schizopherenea, substance abuse disorders, sleep disorders or epilepsy.
Claims19
A method of treating schizophrenia, which comprises administering to a subject in need thereof an effective amount a compound of formula (Ia):
- wherein:
- R1 is halo, C1-4 alkyl, C1-4 alkoxy, halo-C1-4alkyl, halo-C1-4alkoxy, or cyano;
- R2 is H, halo, cyano, C1-4 alkyl or C1-4 alkoxy;
- with the proviso that when R2 is H, R1 is not in the para position;
- X is CH or N;
- Y is CH or N;
- R3 is C1-4 alkyl;
- R4 is H, deuterium, or C1-4alkyl;
- or R3 and R4 can be fused to form a C3-4 spiro carbocyclyl group;
- or a pharmaceutically acceptable salt thereof.
A method for the prophylaxis of schizophrenia, which comprises administering to a subject in need thereof an effective amount a compound of formula (Ia):
- wherein:
- R1 is halo, C1-4 alkyl, C1-4 alkoxy, halo-C1-4alkyl, halo-C1-4alkoxy, or cyano;
- R2 is H, halo, cyano, C1-4 alkyl or C1-4 alkoxy;
- with the proviso that when R2 is H, R1 is not in the para position;
- X is CH or N;
- Y is CH or N;
- R3 is C1-4 alkyl;
- R4 is H, deuterium, or C1-4alkyl;
- or R3 and R4 can be fused to form a C3-4 spiro carbocyclyl group;
- or a pharmaceutically acceptable salt thereof.
A method for the treatment or prophylaxis of hyperactivity, which comprises administering to a subject in need thereof an effective amount a compound of formula (Ia):
- wherein:
- R1 is halo, C1-4 alkyl, C1-4 alkoxy, halo-C1-4alkyl, halo-C1-4alkoxy, or cyano;
- R2 is H, halo, cyano, C1-4 alkyl or C1-4 alkoxy;
- with the proviso that when R2 is H, R1 is not in the para position;
- X is CH or N;
- Y is CH or N;
- R3 is C1-4 alkyl;
- R4 is H, deuterium, or C1-4alkyl;
- or R3 and R4 can be fused to form a C3-4 spiro carbocyclyl group;
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.