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US 9,849,126 B2Granted
Sterile otic formulations
AssigneeEntrx LLC
InventorsMatthew Branch, Vance Oglesbee
Life of this patent
Estimating the term…
Abstract
The present disclosure describes a sterile formulation and method for treating an ear infection, especially otomycosis and otitis externa, by administering a one-time only treatment comprising an antibiotic, and antifungal, and an optional anti-inflammatory in a thick, otic carrier. In one embodiment, the sterilization comprises e-beam irradiating ingredients the formulation while heat-sterilizing other ingredients before combining under sterile condition.
Claims14
A single-dose formulation for treating ear infection, comprising:
- a) active ingredients for treating fungal and bacterial infections, comprising:
- i) ciprofloxacin;
- ii) an azole antifungal;
- and,
- iii) dexamethasone;
- b) an otically acceptable carrier that includes at least one thickener so that the single-dose formulation is capable of a one-time delivery to the ear canal of a mammal in a flowable fluid form but upon introduction into the ear canal the formulation remains in the ear canal for at least 3 days releasing said active ingredients.
3 more elements
A sterile single-dose formulation for treating ear infection, comprising:
- a) active ingredients for treating fungal and bacterial infection comprising:
- i) about 0.3% by weight of ciprofloxacin;
- ii) about 1% by weight of a clotrimazole;
- iii) about 0.1% by weight of a dexamethasone;
- and
- b) about 10-25% of wax;
- and
- c) about 75-90% of mineral oil;
- d) wherein said ciprofloxacin and clotrimazole are sterilized with heat treatment at a temperature of at least 120° C. for 1-3 hours.
6 more elements
Dependencies are inferred from the claim text.