Protein tyrosine phosphatase inhibitor, preparation method and uses thereof
AssigneeHeibei University
InventorsDuqiang Luo, Jun Zhang, Zhiqin Liu
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Abstract
Disclosed in the present invention is a protein tyrosine phosphatase inhibitor. The preparation method therefor is: extracting the crude product from the Isaria Fumosorosea Wize solid or liquid fermentation broth using ethyl acetate, ethanol, methanol, or a mixed solvent of chloroform and methanol; separating the obtained extract using column chromatography on silica gel; and obtaining the target product. The inhibitor can be used to prepare pharmaceutical compositions for treating and preventing diabetes, obesity and cancers.
Claims4
A method for preparing a substantially isolated protein tyrosine phosphatase inhibitor having the following structural formula:
- the method comprising:
- extracting a solid or liquid fermentation broth of entomogenous fungus Isaria Fumosorosea Wize with ethyl acetate, ethanol, methanol, or a mixed solvent of chloroform and methanol;
- separating the resulting extract by column chromatography on silica gel;
- and obtaining the substantially isolated protein tyrosine phosphatase inhibitor, Fumosorinone.
Dependencies are inferred from the claim text.