Autotaxin inhibitors and uses thereof

A method of treating cancer in a mammal, comprising administering a therapeutically effective amount of a compound of Formula (I), or a pharmaceutically acceptable salt thereof to a mammal in need thereof, where a compound of Formula (I) comprises:

• wherein,
• R1 is H, substituted or unsubstituted C1-C6alkyl, substituted or unsubstituted C1-C6-fluoroalkyl, substituted or unsubstituted C1-C6heteroalkyl, substituted or unsubstituted C3-C6cycloalkyl, substituted or unsubstituted phenyl, substituted or unsubstituted monocyclic heteroaryl, or -L1-R4;
• L1 is substituted or unsubstituted C1-C6alkylene, substituted or unsubstituted phenylene, or substituted or unsubstituted monocyclic heteroarylene;
• R4 is substituted or unsubstituted C3-C6cycloalkyl, substituted or unsubstituted phenyl, substituted or unsubstituted benzyl, substituted or unsubstituted naphthyl, or substituted or unsubstituted monocyclic heteroaryl;
• R2 is H, C1-C4alkyl, or C1-C4-fluoroalkyl;
• X is —O— or —S—, provided that if X is —O—, L2 is not absent;
• L2 is absent, C1-C6alkylene, or C3-C6cycloalkylene;
• RA is —CO2H, —CO2(C1-C6alkyl), —OH, —CN, —B(OH)2, —C(═O)NHSO2R9, —C(═O)N(R10)2, —C(═O)NHCH2CH2N(CH3)2, —C(═O)NHCH2CH2N(CH3)3, —C(═O)NH—OH, —C(═O)NH—CN, —SO2NHC(═O)R9, —CN, tetrazolyl or carboxylic acid bioisostere;
• R3 and R5 are each independently H, halogen, —CN, —OH, C1-C4alkyl, C1-C4alkoxy, —S—C1-C4alkyl, C1-C4-fluoroalkyl, C1-C4-fluoroalkoxy, and C1-C4heteroalkyl;
• R6 is H, halogen, —CN, —NO2, —OH, —OR9, —SR9, —S(═O)R9, —S(═O)2R9, —S(═O)2N(R10)2, —NR10S(═O)2R9, —C(═O)R9, —OC(═O)R9, —CO2R10, —OCO2R9, —N(R10)2, —C(═O)N(R10)2, —OC(═O)N(R10)2, —NHC(═O)R9, —NHC(═O)OR9, C1-C4alkyl, C1-C4alkoxy, —S—C1-C4alkyl, —S(O)2-C1-C4alkyl, C1-C4-fluoroalkyl, C1-C4-fluoroalkoxy, C1-C4heteroalkyl, C3-C6cycloalkyl, substituted or unsubstituted phenyl, substituted or unsubstituted monocyclic heteroaryl;
• R9 is C1-C6alkyl, C3-C6cycloalkyl, a substituted or unsubstituted phenyl, or a substituted or unsubstituted monocyclic heteroaryl;
• each R10 is independently selected from H, C1-C6alkyl, C3-C6cycloalkyl, a substituted or unsubstituted phenyl, or a substituted or unsubstituted monocyclic heteroaryl;
• or
• two R10 groups attached to the same N atom are taken together with the N atom to which they are attached to form a substituted or unsubstituted heterocycle.