Method for enhancing amidohydrolase activity of fatty acid amide hydrolase
AssigneesResearch Foundation of the City University of New York, The Curators of the University of Missouri, University of North Texas
InventorsGeorge John, Subbiah Nagarajan, Kent Chapman, Lionel Faure, Peter Koulen
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Abstract
A method for enhancing amidohydrolase activity of Fatty Acid Amide Hydrolase (FAAH) is disclosed. The method comprising administering a phenoxyacyl-ethanolamide that causes the enhanced activity. The enhanced activity can have numerous effects on biological organisms including, for example, enhancing the growth of certain seedlings.
Claims15
A method for enhancing amidohydrolase activity of fatty acid amide hydrolase in an animal, the method comprising
- administering a composition of matter consisting essentially of a phenoxyacyl-ethanolamide to the animal such that hydrolysis of N-acylethanolamines (NAEs) by fatty acid amide hydrolase (FAAH) in the animal is enhanced relative to a substantially identical animal that has not been administered with the phenoxyacyl-ethanolamide, wherein the phenoxyacyl-ethanolamide is represented by a structure:
- wherein R is an aliphatic side chain.
A method for enhancing amidohydrolase activity of fatty acid amide hydrolase in an animal, the method comprising administering a phenoxyacyl-ethanolamide composition to an animal such that hydrolysis of N-acylethanolamines (NAEs) by fatty acid amide hydrolase (FAAH) in the animal is enhanced relative to a substantially identical animal that has not been administered with the phenoxyacyl-ethanolamide composition, wherein the phenoxyacyl-ethanolamide composition is represented by a structure:
- wherein R is an aliphatic side chain;
- wherein the aliphatic side chain has at least one double bond.
A method for enhancing amidohydrolase activity of fatty acid amide hydrolase in an animal, the method comprising administering composition of matter consisting of a phenoxyacyl-ethanolamide to an animal such that hydrolysis of N-acylethanolamines (NAEs) by fatty acid amide hydrolase (FAAH) in the animal is enhanced relative to a substantially identical animal that has not been administered with the phenoxyacyl-ethanolamide, wherein the phenoxyacyl-ethanolamide is represented by a structure:
- wherein R is an aliphatic side chain with between twelve and twenty carbons.
A method for enhancing amidohydrolase activity of fatty acid amide hydrolase in an animal, the method comprising
- administering a phenoxyacyl-ethanolamide composition to an animal such that hydrolysis of N-acylethanolamines (NAEs) by fatty acid amide hydrolase (FAAH) in the animal is enhanced relative to a substantially identical animal that has not been administered with the phenoxyacyl-ethanolamide composition, wherein the phenoxyacyl-ethanolamide composition is represented by a structure:
- wherein R is an aliphatic side chain with between twelve and twenty carbons, wherein the aliphatic side chain has at least one double bond.
A method for enhancing amidohydrolase activity of fatty acid amide hydrolase in an animal, the method comprising administering a composition of matter consisting essentially of a phenoxyacyl-ethanolamide to a mammal such that hydrolysis of N-acylethanolamines (NAEs) by fatty acid amide hydrolase (FAAH) in the mammal is enhanced relative to a substantially identical mammal that has not been administered with the phenoxyacyl-ethanolamide, wherein the phenoxyacyl-ethanolamide is represented by a structure:
- wherein R is a saturated aliphatic side chain with between twelve and twenty carbons.
Dependencies are inferred from the claim text.