Antimicrobial compounds, compositions and methods of use thereof
AssigneeWisconsin Alumni Research Foundation
InventorsDouglas Benjamin Weibel, Katherine Ann Hurley, Katherine Cassidy Faulkner
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Abstract
Described herein are antimicrobial compounds identified via a high-throughput screen to identify compounds that produce anucleate cells in E. coli after cell division occurs. Compound 1 (5-nonyloxytryptamine) and its analogs are small molecule inhibitors of the nucleoid occlusion system and/or proteins that are responsible for maintaining the structure of the chromosome. The antimicrobial compounds are useful to treat bacterial infections as well as to inhibit bacterial growth.
Claims18
A method of treating a subject in need of treatment for a bacterial infection comprising administering to the subject a compound of Formula III or IV, or a pharmaceutically acceptable salt thereof,
- wherein R is a substituted or unsubstituted C5-C18 alkyl group, a substituted or unsubstituted C5-C18 alkenyl group, a substituted or unsubstituted C5-C18 alkynyl group, a substituted or unsubstituted C5-C18 cycloalkyl group, a substituted or unsubstituted C6-C18 cycloalkenyl group, or a substituted or unsubstituted C8-C18 cycloalkynyl group.
A method of inhibiting bacterial growth comprising contacting bacteria with an antimicrobially effective amount of a compound of Formula III or IV, or a pharmaceutically acceptable salt thereof,
- wherein R is a substituted or unsubstituted C5-C18 alkyl group, a substituted or unsubstituted C5-C18 alkenyl group, a substituted or unsubstituted C5-C18 alkynyl groups substituted or unsubstituted C5-C18 cycloalkyl group, a substituted or unsubstituted C6-C18 cycloalkenyl group, or a substituted or unsubstituted C8-C18 cycloalkynyl group.
Dependencies are inferred from the claim text.