Early cancer detection and enhanced immunotherapy
OwnerGholam A. Peymaninventor
Life of this patent
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Abstract
A method of therapy for a tumor or other pathology by administering a combination of thermotherapy and immunotherapy optionally combined with gene delivery. The combination therapy beneficially treats the tumor and prevents tumor recurrence, either locally or at a different site, by boosting the patient's immune response both at the time or original therapy and/or for later therapy. With respect to gene delivery, the inventive method may be used in cancer therapy, but is not limited to such use; it will be appreciated that the inventive method may be used for gene delivery in general. The controlled and precise application of thermal energy enhances gene transfer to any cell, whether the cell is a neoplastic cell, a pre-neoplastic cell, or a normal cell.
Claims11
A cancer therapeutic method comprising administering to a patient having an early stage tumor a combination of thermotherapy and immunotherapy, where
- thermotherapy comprises systemically administering a tumor-antibody-coated nanoparticle coated with a thermosensitive polymer, the thermotherapy further comprises heating the tumor-antibody-coated nanoparticle using an energy source at the site of the tumor so as to damage one or more tumor cell membranes and release antigenic material in vivo that activates and stimulates an immunogenic response of the patient at the site of the tumor;
- and
- immunotherapy comprises systemically administering the patient's natural killer (NK) cells/dendritic cells pre-sensitized in vitro to the tumor, the immunotherapy further comprises administering NK cells/dendritic cells containing viral like particles (VLP) to the patient.
Dependencies are inferred from the claim text.