Solid oral formulations having an iron sugar overcoat
OwnerJugal K. Tanejainventor
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Abstract
This invention provides a solid oral formulation including a tablet core surrounded by an iron sugar overcoat so that the iron sugar overcoat makes at least some elemental iron content available for gastrointestinal absorption relative to the tablet core while counteracting at least some of the constipation associated with oral iron consumption, and further includes methods of administering the solid oral formulation.
Claims22
A solid oral formulation including a tablet core and an iron sugar overcoat;
- said tablet core including at least one therapeutic ingredient, said tablet core further surrounded by said iron sugar overcoat;
- said iron sugar overcoat including at least one form of bioavailable iron and at least one sugar, said at least one form of bioavailable iron and said at least one sugar each in an amount of at least 0.01 mg, said iron sugar overcoat making available at least some elemental iron content for gastrointestinal absorption prior to release of said at least one therapeutic ingredient of said tablet core;
- said at least one sugar of said iron sugar overcoat further having some laxative effect that counteracts at least some constipation associated with oral iron consumption.
A solid oral formulation including a tablet core and an iron sugar overcoat;
- said tablet core including at least one therapeutic ingredient, said tablet core further surrounded by said iron sugar overcoat;
- said iron sugar overcoat including at least one form of bioavailable iron and at least one sugar, said at least one form of bioavailable iron and said at least one sugar each in an amount of at least 0.01 mg, said iron sugar overcoat making available at least some elemental iron content for gastrointestinal co-absorption with said at least one therapeutic ingredient of said tablet core.
An at least two-phase method including a phase-one step of administering daily, for at least three weeks, an at least one dosage of a first solid oral formulation, said first solid oral formulation including a tablet core and an iron sugar overcoat including at least one form of iron in an amount of at least 0.01 mg and at least one sugar in an amount of at least 0.01 mg having some laxative effect that counteracts at least some constipation associated with oral iron consumption, said first solid oral formulation including iron in a higher initial amount sufficient to be available for gastrointestinal absorption for treating iron deficiency/iron deficiency anemia;
- said method further including a phase-two step of reducing said administering daily of said at least one dosage of said first solid oral formulation after the at least three weeks from when dosage administration of said first solid oral formulation began in phase-one;
- while concomitantly administering daily at least one dosage of a second solid oral formulation, said second solid oral formulation including a tablet core and an iron sugar overcoat including at least one form of iron in an amount of at least 0.01 mg and at least one sugar in an amount of at least 0.01 mg having some laxative effect that counteracts at least some constipation associated with oral iron consumption, said second solid oral formulation including iron in a lower subsequent amount sufficient to be available for gastrointestinal absorption for replenishing/maintaining iron levels and preventing recurrence of iron deficiency/iron deficiency anemia;
- said second solid oral formulation having an elemental iron equivalent content less than that of said first solid oral formulation.
Dependencies are inferred from the claim text.