Methods and compositions for X-ray induced release from pH sensitive liposomes
AssigneeBoard of Trustees of the University of Arkansas
InventorsDaniel Fologea, Ralph Henry, Greg Salamo, Yuriy Mazur, Michael J. Borrelli
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Abstract
Compositions including pH sensitive lipid vesicles comprised of a lipid layer, an agent, and an organic halogen such that the agent is released from the vesicles after exposure to ionizing radiation. Methods of delivering the agent to a target in a subject using the compositions provided herein are also described. The methods allow for controlled release of the agent. The timing of release of the agent from the lipid vesicle may be controlled as well as the location of release by timing and localizing the exposure to ionizing radiation exposure.
Claims16
A pH sensitive lipid vesicle composition comprising a lipid layer surrounding an aqueous medium configured for the controlled release of an agent upon exposure to ionizing radiation, the aqueous medium comprising the agent and an organic halogen and the lipid layer comprising a pH sensitive lipid,
- wherein the organic halogen is chloral hydrate and has a concentration of between 0.1M and 1.0M in the aqueous medium within the vesicle and
- wherein exposure of the aqueous medium to ionizing radiation increases the acidity of the aqueous medium and allows the agent to be released from the lipid vesicle.
Dependencies are inferred from the claim text.