Sublingual administration of statins
AssigneeLondonPharma Ltd.
InventorsMartin James Sams, Juliet Victoria High, Paul Andrew Jamieson, Clive Booles
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Abstract
The invention provides a pharmaceutical composition for the transmucosal delivery of a statin, said composition comprising a statin and a carrier in which said statin is soluble or forms a suspension or emulsion. The invention also provides a pharmaceutical composition comprising a statin for use in inhibiting cholesterol synthesis in vivo, where in said use said composition is delivered by the transmucosal route.
Claims20
A method of preventing cardiovascular disease or treating hypercholesterolaemia, dyslipidaemia, or cardiovascular disease;
- or an effect of any of these conditions, in a human individual, comprising delivering a composition by transmucosal sublingual or transmucosal buccal administration as a spray wherein said composition comprises a statin selected from the group consisting of simvastatin, atorvastatin, lovastatin, pitavastatin, or a salt thereof, a carrier that comprises an oil that comprises a glyceride, wherein said statin is solubilised in said carrier, and from about 5% to about 35% v/v of an ethanol co-solvent.
A method of preventing cardiovascular disease or treating hypercholesterolaemia, dyslipidaemia, or cardiovascular disease;
- or an effect of any of these conditions, in a human individual, comprising delivering a composition by transmucosal sublingual or transmucosal buccal administration as a spray wherein the composition comprises at least about 80 mg/ml simvastatin or a salt thereof, a medium chain triglyceride (Ph Eur), and from about 5% to about 35% v/v ethanol.
Dependencies are inferred from the claim text.