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US 9,848,987 B2Granted
Joint bioscaffolds
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsStephen F. Badylak, Bryan N. Brown, William L. Chung
Life of this patent
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Abstract
Provided herein are compositions and medical devices, and in particular, biodegradable scaffolds capable of repairing and replacing cartilagenous meniscuses. Also provided herein are methods of using scaffolds for treating degenerative tissue disorders. In certain embodiments, such scaffolds can promote tissue regeneration of a temporal mandibular joint (TMJ) meniscus.
Claims21
A bioscaffold for replacement and regeneration of a temporomandibular joint (TMJ) meniscus, the bioscaffold comprising:
- a biocompatible, biodegradable, elastomeric implant dimensioned to fit within the TMJ and mimic the size and function of a native TMJ meniscus, the implant comprising a raised central core having a curved top surface, and the core is surrounded by a substantially flat peripheral brim extending around the core, wherein the core comprises a gel or particulate powder extracellular matrix and has a circular or elliptical base and a height above the base and composition that permits the core to elastically deform under stress, and a diameter of the core is sufficient for the core to carry shear forces between the mandible and the skull when the implant is affixed to an articulating condylar head of a mandible or a zygomatic bone in the TMJ as a replacement for a TMJ meniscus following TMJ meniscectomy.
Dependencies are inferred from the claim text.