Methods and devices for localized disease treatment by ablation
AssigneeMedtronic Ardian Luxembourg S.a.r.l.
InventorsAyala Hezi-Yamit, Susan Edwards, Carol Sullivan
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Abstract
Provided herein are methods, systems, and devices for increasing heat shock protein expression and treating conditions for which increased heat shock protein expression is expected to be beneficial using thermal ablation.
Claims20
A method for increasing a heat shock protein (HSP) expression level at or near a target site in a subject, the method comprising:
- determining a baseline HSP expression level for one or more HSPs at or near the target site in the subject;
- performing a thermal ablation procedure at or near the target site;
- determining a post-ablation HSP expression level for the one or more HSPs at or near the target site in the subject;
- and
- comparing the post-ablation HSP expression level to the baseline HSP expression level,
- wherein the thermal ablation procedure is classified as successful if the post-ablation HSP expression level is increased from the baseline HSP expression level.
A method for treating a condition for which increased HSP expression is expected to be beneficial in a subject, the method comprising:
- intravascularly positioning a catheter carrying an ablation assembly within a target blood vessel of the subject;
- target tissue proximate the target blood vessel via the ablation assembly to thermally ablate the target tissue, wherein thermal ablation of the target tissue results in an increase in a HSP expression level;
- and
- after delivering energy to the target tissue, quantifying the HSP expression level and comparing the HSP expression level to a pre-determined threshold expression level for the HSP,
- wherein the HSP expression level is beneficial in the treatment of the condition if the HSP expression level is greater than the pre-determined threshold expression level.
A method for treating a condition for which increased HSP expression is expected to be beneficial in a patient, the method comprising performing a thermal ablation procedure at a target site, wherein the target site is within a blood vessel of the patient, and wherein the thermal ablation procedure results in an increase in the expression level of one or more HSPs at a location remote to the target site.
A method for treating a condition associated with an affected tissue for which increased HSP expression is expected to be beneficial in a human patient, the method comprising:
- intravascularly positioning a catheter carrying an ablation assembly within a target blood vessel proximate the affected tissue of the patient;
- and
- delivering energy through a wall of the target blood vessel to target tissue proximate the blood vessel via the ablation assembly to at least partially thermally ablate the target tissue, wherein thermal ablation of the target tissue results in an increase in a HSP expression level at or near the affected tissue in the patient,
- wherein the increase in the HSP expression level is at least partially beneficial in the treatment of the condition.
Dependencies are inferred from the claim text.