3-hydroxypropionic acid production by recombinant yeasts expressing an insect aspartate 1-decarboxylase
AssigneeNovozymes A/S
InventorsMichelle Barnhart, Ana Negrete-Raymond, Janice Frias, Gui Barbier, Michael Catlett
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Abstract
Provided herein are recombinant yeast cells having an active 3-Hydroxypropionic Acid (3-HP) pathway and further comprising a heterologous polynucleotide encoding an aspartate 1-decarboxylase (ADC) of the Class Insecta, Bivalvia, Branchioporia, Gastropoda, or Leptocardii. Also described are methods of using the recombinant yeast cells to produce 3-HP and acrylic acid.
Claims20
A recombinant yeast cell comprising a heterologous polynucleotide encoding an aspartate 1-decarboxylase, wherein the aspartate 1-decarboxylase has at least 95% sequence identity to the amino acid sequence of SEQ ID NO:
- 162, and wherein the cell is capable of producing 3-hydroxypropionic acid (3-HP).
Dependencies are inferred from the claim text.