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US 9,845,463 B2Granted
Methods and columns for nucleic acid purification
AssigneeNorgen Biotek Corp.
InventorYousef Haj-Ahmad
Life of this patent
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Abstract
Provided are methods and columns employing a solid support comprising silica and silicon carbide for the isolation and purification of nucleic acids, and in particular, the isolation and purification of both high and low molecular weight RNA.
Claims14
A column for isolating nucleic acids, the column comprising:
- a housing comprising an inlet opening and an outlet opening;
- and
- a solid support disposed within the housing between the inlet and outlet openings, the solid support comprising silica and silicon carbide, wherein:
- (a) the solid support comprises a plurality of layers, each of the layers comprising the silica, the silicon carbide or a combination thereof and wherein at least two layers are different;
- or
- (b) the solid support comprises a mixture of the silica and the silicon carbide in an approximately 1:1 weight ratio.
3 more elements
Dependencies are inferred from the claim text.