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US 9,845,460 B2Granted
Treatment of pluripotent cells
AssigneeJanssen Biotech, Inc.
InventorsJanet Davis, Jiajian Liu
Life of this patent
Estimating the term…
Abstract
The present invention is provides a method for treating human pluripotent cells. In particular, the methods of the invention are directed to the treatment of human pluripotent cells, whereby the human pluripotent cells can be efficiently expanded in culture and differentiated by treating the pluripotent cells with an inhibitor of glycogen synthase kinase 3β (GSK-3B) enzyme activity.
Claims9
A method to expand and differentiate human embryonic stem cells, comprising the steps of:
- a. Culturing human embryonic stem cells, and
- b. Treating the human embryonic stem cells with an inhibitor of glycogen synthase kinase 3β (GSK-3B) enzyme activity, wherein the inhibitor is 3-[1-(3-hydroxy-propyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-4-pyrazin-2-yl-pyrrole-2,5-dione.
Dependencies are inferred from the claim text.