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US 9,845,361 B2Granted
Recognition molecules for the treatment and detection of tumors
AssigneeGlycotope GmbH
InventorsSteffen Goletz, Antje Danielczyk, Renate Stahn, Uwe Karsten
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Abstract
The invention relates to recognition molecules directed towards tumors, and it also relates to pharmaceutical compositions comprising said recognition molecules, methods for the production of said recognition molecules, and to the use of said recognition molecules in the diagnosis and therapy of tumor diseases.
Claims7
A method of providing a molecule for tumor recognition comprising,
- a. providing a recombinant recognition molecule which comprises a variable heavy chain and a variable light chain and which specifically binds to a glycosylated MUC1 tumor epitope, wherein
- the variable heavy chain comprises (i) a CDRH1 region that comprises the amino acid sequence of SEQ ID NO:
- 1 or 2;
- (ii) a CDRH2 region that comprises the amino acid sequence of SEQ ID NO:
- 3 or 4;
- and (iii) a CDRH3 region that comprises the amino acid sequence of SEQ ID NO:
- 5 or 6;
- and
- the variable light chain comprises (i) a CDRL1 region that comprises the amino acid sequence of SEQ ID NO:
- 7 or 8;
- (ii) a CDRL2 region that comprises the amino acid sequence of SEQ ID NO:
- 9 or 10;
- and (iii) a CDRL3 region that comprises the amino acid sequence of SEQ ID NO:
- 11 or 12;
- b. modifying the recombinant recognition molecule by one or more mutations in one or more amino acid sequences set forth in step a., wherein single amino acids are replaced by amino acids having analogous physicochemical properties,
- c. selecting a recombinant recognition molecule modified in step b. that retains binding specificity towards the glycosylated MUC1 tumor epitope, and
- d. providing the modified recombinant recognition molecule selected in step c.
14 more elements
Dependencies are inferred from the claim text.