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US 9,845,358 B2Granted
Anti-inflammatory polypeptides
AssigneeThe Rockefeller University
InventorsJeffrey V. Ravetch, Andrew Pincetic
Life of this patent
Estimating the term…
Abstract
This invention concerns anti-inflammatory agents, compositions, and methods for treating inflammatory disorders.
Claims14
method of increasing a level of regulatory T (Treg) cells in a subject in need thereof, comprising administering to the subject an effective amount of
- an isolated polypeptide, or a nucleic acid encoding the isolated polypeptide, comprising a modified sequence, wherein the IgG Fc region comprises the sequence of SEQ ID NO:
- 1, and wherein the modified sequence is at least 95% identical to SEQ ID NO:
- 1 and has a F to A mutation at a position corresponding to F32 of SEQ ID NO:
- 1.
1 more element
A method of treating a T cell-mediated autoimmune disease in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of
- an isolated polypeptide, or a nucleic acid encoding the isolated polypeptide, comprising a modified sequence, wherein the modified sequence is at least 95% identical to SEQ ID NO:
- 1and has a F-to-A mutation at a position corresponding to position F32 of SEQ ID NO:
- 1, and wherein the first or second isolated polypeptide has an ability to bind to DC-SIGN, hFcγRIIA, or hFcγRIIB.
Dependencies are inferred from the claim text.