Single agent anti-PD-L1 and PD-L2 dual binding antibodies and methods of use
AssigneesDana-Farber Cancer Institute, Inc., President and Fellows of Harvard College
InventorsGordon J. Freeman, Arlene H. Sharpe
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Abstract
The present invention is based, in part, on the identification of novel antibodies that have binding affinity for both PD-L1 and PD-L2 and methods of using same. In one aspect, an isolated monoclonal antibody, or antigen-binding fragment thereof, which specifically binds both PD-L1 and PD-L2, is provided. In one embodiment, both PD-L1 and PD-L2 are human PD-L1 and human PD-L2.
Claims30
An isolated monoclonal antibody, or antigen-binding fragment thereof, that specifically binds both PD-L1 and PD-L2 comprising six CDRs:
- CDR-L1, CDR-L2, CDR-L3, CDR-H1, CDR-H2, and CDR-H3, wherein CDR-L1 consists of the amino acid sequence encoded by nucleotides 70-102 of SEQ ID NO:
- 13, CDR-L2 consists of the amino acid sequence encoded by nucleotides 148-168 of SEQ ID NO:
- 13, CDR-L3 consists of the amino acid sequence encoded by nucleotides 265-291 of SEQ ID NO:13, CDR-H1 consists of the amino acid sequence encoded by nucleotides 91-108 of SEQ ID NO:
- 15, CDR-H2 consists of the amino acid sequence encoded by nucleotides 151-198 of SEQ ID NO:
- 15, and CDR-H3 consists of the amino acid sequence encoded by nucleotides 295-330 of SEQ ID NO:
- 15.
An isolated monoclonal antibody, or antigen-binding fragment thereof, that specifically binds both PD-L1 and PD-L2 comprising six CDRs:
- CDR-L1, CDR-L2, CDR-L3, CDR-H1, CDR-H2, and CDR-H3, wherein CDR-L1 consists of the amino acid sequence encoded by nucleotides 70-102 of SEQ ID NO:
- 17, CDR-L2 consists of the amino acid sequence encoded by nucleotides 148-168 of SEQ ID NO:
- 17, CDR-L3 consists of the amino acid sequence encoded by nucleotides 265-291 of SEQ ID NO:
- 17, CDR-H1 consists of the amino acid sequence encoded by nucleotides 91-108 of SEQ ID NO:
- 19, CDR-H2 consists of the amino acid sequence encoded by nucleotides 151-198 of SEQ ID NO:
- 19, and CDR-H3 consists of the amino acid sequence encoded by nucleotides 295-330 of SEQ ID NO:
- 19.
Dependencies are inferred from the claim text.