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US 9,845,355 B2Granted
Humanized anti-CD79b antibodies and immunoconjugates and methods of use
AssigneeGenentech, Inc.
InventorsYvonne Chen, Mark Dennis, Kristi Elkins, Jagath Reddy Junutula, Andrew Polson, Bing Zheng
Life of this patent
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Abstract
The present invention is directed to anti-CD79b antibodies with specific hypervariable region sequences in the heavy and light chain variable domains as enumerated in the SEQ ID NOs described herein.
Claims23
An anti-CD79b antibody comprising the following hypervariable region (HVR) sequences:
- (i) HVR-L1 comprising sequence A1-A16, wherein A1-A16 is KSSQSLLDSDGKTYLN (SEQ ID NO:
- 59);
- (ii) HVR-L2 comprising sequence B1-B7, wherein B1-B7 is LVSKLDS (SEQ ID NO:
- 60);
- (iii) HVR-L3 comprising sequence C1-C9, wherein C1-C9 is FQGTHFPFT (SEQ ID NO:
- 79);
- (iv) HVR-H1 comprising sequence D1-D10, wherein D1-D10 is GYTFTSYWMN (SEQ ID NO:
- 62);
- (v) HVR-H2 comprising sequence E1-E18, wherein E1-E18 is GMIDPSDSETHYNHIFKD (SEQ ID NO:
- 63);
- and
- (vi) HVR-H3 comprising sequence F1-F6, wherein F1-F6 is ARNLYL (SEQ ID NO:
- 64).
10 more elements
An antibody that binds to CD79b, wherein the antibody comprises a heavy chain variable domain comprising the amino acid sequence of SEQ ID NO:
- 16 and a light chain variable domain comprising the amino acid sequence of SEQ ID NO:
- 12.
Dependencies are inferred from the claim text.