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US 9,845,348 B2Granted
Methods of treating S. aureus-associated diseases
AssigneeMedImmune, LLC
InventorsBrett Sellman, Christine Tkaczyk, Melissa Hamilton, Lei Hua
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AssigneeMedImmune, LLC
InventorsBrett Sellman, Christine Tkaczyk, Melissa Hamilton, Lei Hua
Estimating the term…
The present invention provides for methods of preventing and/or treating S. aureus-associated bacteremia and sepsis, and methods for preventing and/or treating S. aureus-associated pneumonia in immunocompromised patients using anti-S. aureus alpha-toxin (anti-AT) antibodies. Also provided are methods of reducing S. aureus bacterial load in the bloodstream or heart of a mammalian subject comprising administering to the subject an effective amount of an isolated anti-S. aureus alpha toxin (anti-AT) antibody or antigen-binding fragment thereof. Methods of reducing S. aureus bacterial agglutination and/or thromboembolic lesion formation in a mammalian subject comprising administering to the subject an effective amount of an isolated anti-S. aureus alpha toxin (anti-AT) antibody or antigen-binding fragment thereof, are also provided. Also provided are methods of preventing or reducing the severity of S. aureus associated pneumonia in an immunocompromised mammalian subject.
A method of preventing or reducing the severity of S. aureus-associated pneumonia in an immunocompromised mammalian subject, comprising administering to said subject an effective amount of an isolated anti-S. aureus alpha toxin (anti-AT) antibody or antigen-binding fragment thereof, wherein the isolated antibody or antigen-binding fragment thereof immunospecifically binds to a Staphylococcus aureus alpha toxin polypeptide and includes:
Dependencies are inferred from the claim text.