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US 9,845,345 B2Granted
SIRP polypeptide compositions and methods of use
AssigneeAB Initio Biotherapeutics, Inc.
InventorsAaron Michael Ring, Roy Louis Maute, Andrew Curtis Kruse, Aashish Manglik, Kenneth S. Lin
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Abstract
Provided herein are SIRP-gamma, SIRP-beta or SIRP-beta2 decoy polypeptides for immunotherapy and/or treatment of cancer, anemia, transplant, asthma, allergy, auto-immune disease, and viral infection.
Claims23
A polypeptide comprising a SIRP-gamma polypeptide consisting of the sequence EEELQX1IQPEKLLLVTVGKTATLHCTX2TSX3X4PX5GPX6X7WFRGX8GPGRX9LIYNX10X11X12GX13FPRVTTVSDX14X15KRNNMDFSIRISSITPADVGTYYCX16KFRKGX17PEX18VEFK SGPGTEMALGAKPS (SEQ ID NO:
- 2), wherein X1 is M, I, L or F;
- X2 is F, I, or L;
- X3 is L, I, V, H, N or D;
- X4 is F, I, L or V;
- X5 is V, I, L, P, T or A;
- X6 is V or I;
- X7 is L or Q;
- X8 is V or A;
- X9 is E or V;
- X10 is Q, P, L, V, A or E;
- X11 is K or R;
- X12 is E, D, K, N, Q or H;
- X13 is H, P or R;
- X14 is L, I, V, P, T, A, R, S or G;
- X15 is T, I, N, F, S, Y, V, A or D;
- X16 is V or I;
- X17 is S, R, N, K, T, I or M;
- and X18 is N, K, D, E, H or Q, and wherein the SIRP-gamma polypeptide binds CD47.
15 more elements
Dependencies are inferred from the claim text.