Vibro-based delivery system and immune suppression
AssigneeThe Brigham and Women's Hospital, Inc.
InventorsMatthew Waldor, Xiaohui Zhou, Benjamin Gewurz
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Abstract
Embodiments described are immunosuppressant therapeutics and compositions comprising a Vop protein derived from Vibro parahaemolyticus; and drug delivery vehicles derived from a V. parahaemolyticus expressing a mutant VopZ protein lacking amino acid residue 38-62.
Claims1
A method comprising administering to a host subject a composition comprising an isolated live attenuated bacterium comprising a nucleic acid encoding a mutant VopZ protein that lacks at least the amino acid residues 38-62 of SEQ. ID. NO:1, wherein the attenuated bacterium does not cause diarrhea normally associated with Vibro parahaemolyticus in the host subject.
Dependencies are inferred from the claim text.