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US 9,845,340 B2Granted
Peptides that specifically bind HGF receptor (cMet) and uses thereof
AssigneeDyax Corp.
InventorsDaniel T. Dransfield, Aaron K. Sato, Robert Charles Ladner
Life of this patent
Estimating the term…
Abstract
A polypeptide or multimeric polypeptide construct having the ability to bind to cMet or a complex comprising cMet and HGF, and methods for use are disclosed.
Claims14
An isolated polypeptide which binds cMet or a complex comprising cMet and HGF, wherein the polypeptide comprises the amino acid sequence selected from the group consisting of:
- (a) GSX1X2X3CX4X5X6X7CX8X9X10APGGK (SEQ ID NO:525), in which
- X1 is F, L, S, W, Y, or M;
- X2 is I, Y, H, T, or N;
- X3 is I, L, D, M, F, or S;
- X4 is P, R, W, N, or E;
- X5 is W, Y, E, P, L, T, or G;
- X6 is S, T, D, F, E, W, G, or Q;
- X7 is F, W, N, Q, E, R, or A;
- X8 is G, N, H, R, M, I, D, V, or T;
- X9 is S, K, F, M, T, D, or L;
- and
- X10 is S, P, T, L, Y, N, H, Q, or W.
9 more elements
Dependencies are inferred from the claim text.