Tetracyclic pyridone compounds as antivirals

A compound of formula (I):

• wherein:
• R1 is halo or C1-C3 alkyl;
• R2 is H, halo, CN, C1-C3 alkyl, C1-C3 haloalkyl, or C1-C3 alkoxy;
• R3 is OH, halo, CN, C1-C3 alkyl, C3-C6 cycloalkyl, C1-C3 haloalkyl, C1-C3 alkoxy, or C1-C3 haloalkoxy;
• R4 is selected from R11, —OR11, —SR11, and —NRR11;
• R11 is C1-C4 alkyl, C3-C6 cycloalkyl, oxetanyl, tetrahydrofuranyl, or tetrahydropyranyl, each of which is optionally substituted with up to three groups selected from halo, CN, —OR, C1-C3 haloalkoxy, —NR2, and a 4-7 membered heterocyclic group containing one or two heteroatoms selected from N, O and S as ring members that is optionally substituted with one or two groups selected from halo, oxo, CN, R, —OR, and —NR2;
• R is independently selected at each occurrence from H and C1-C3 alkyl optionally substituted with one to three groups selected from halo, —OH, C1-C3 alkoxy, oxo, CN, —NH2, —NH(C1-C3 alkyl), —N(C1-C3 alkyl)2, and cyclopropyl;
• and two R groups directly attached to the same atom, which may be C or N, can optionally be taken together to form a 3-6 membered ring that can optionally contain an added heteroatom selected from N, O and S as a ring member, and can be substituted by up to two groups selected from —OH, oxo, C1-C3 alkyl, and C1-C3 alkoxy;
• R5 is H, halo, CN, C1-C3 alkyl, or C1-C3 haloalkyl;
• R6 is H, halo, C1-C3 alkoxy, or C1-C6 alkyl;
• R7 is H, halo, C1-C3 alkoxy, or C1-C6 alkyl;
• R8 is H or C1-C6 alkyl;
• R9 taken together with one group selected from R6, R7 and R8 forms a 3-7 membered cycloalkyl ring or a 3-7 membered heterocyclic ring containing N, O or S as a ring member;
• wherein the cycloalkyl or heterocyclic ring is optionally substituted with up to three groups selected from R, —OR, —NR2, halo, CN, COOR, CONR2, and oxo;
• W is —COOR10, —C(O)NH—SO2R, —C(O)NH—SO2NR2, 5-tetrazolyl, or 1,2,4-oxadiazol-3-yl-5(4H)-one;
• R10 is H or C1-C6 alkyl that is optionally substituted with one or two groups selected from halo, —OR, oxo, CN, —NR2, COOR, and CONR2;
• or a pharmaceutically acceptable salt thereof.