Protein kinase C inhibitors and methods of their use

A compound of formula II

• or a pharmaceutically acceptable salt thereof, wherein:
• X is N or CR;
• R, R2, R3 and R4 are each independently H, 2H, halo, hydroxy (—OH), C1-3 alkoxy, C1-3 haloalkyl or C1-3 alkyl, said C1-3 alkyl optionally substituted with hydroxyl, halo, C1-3 alkoxy or C1-3 haloalkoxy;
• R5 is independently H, 2H, CH3, CH2F, CHF2, CF3, CH2OH, C1-3 alkyl, said C1-3 alkyl optionally substituted with F, OH, C1-3 alkoxy or C1-3 haloalkoxy;
• R5a and R5b are each independently H, 2H, C1-3 alkyl, said C1-3 alkyl optionally substituted with F, OH or C1-3 alkoxy, or R5a and R5b are joined together forming a methylene or ethylene bridging group;
• R5c and R5d are each independently H, 2H, F, —OH, C1-3 alkoxy, C1-3 alkyl, said C1-3 alkyl optionally substituted with F, OH or C1-3 alkoxy, or R5c and R5d are joined together forming a methylene, ethylene or —CH2—O— bridging group;
• R6, R7 and R8 are each independently selected from H, 2H, halo, C1-3 alkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C3-7 cycloalkyl and 4-7 membered heterocyclyl having 1 to 3 heteroatoms selected from N, O and S, said C1-3 alkyl optionally substituted with F, OH, C1-3 alkoxy or C1-3 haloalkoxy;
• or
• wherein R6 and R8 optionally forms a partially saturated carbobicyclic ring or heterobicyclic ring with the heteroaryl ring, said carbobicyclic ring or heterobicyclic ring optionally substituted with 1 to 3 groups selected from:
• 2H, halo, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C3-7 cycloalkyl and 4-7 membered heterocyclyl having 1 to 3 heteroatoms selected from N, O and S.