Isoindoline inhibitors of ROR-gamma

A compound of the Formula:

• or a pharmaceutically acceptable salt thereof, wherein
• R2 is (C1-C3)alkyl;
• R3 is hydrogen, monocyclic cycloalkyl, monocyclic heterocyclyl, or (C1-C6)alkyl, wherein the (C1-C6)alkyl is optionally substituted with 1 to 2 groups independently selected from hydroxy, halo, and cyano;
• R4 is hydrogen, (C1-C3)alkyl, or ═O;
• X is —C(O)NH— or —NHC(O)—;
• m is 0, 1, or 2;
• n is 0, 1, 2, or 3;
• Cy1 is phenyl or pyridinyl, each of which is optionally substituted with 1 to 2 groups independently selected from R5;
• Cy2 is cyclohexyl or phenyl, each of which is optionally substituted with 1 to 2 groups independently selected from R6;
• R5 is (C1-C3)alkylsulfonyl;
• R6 is selected from (C1-C3)alkyl, halo(C1-C3)alkyl, hydroxy, and (C1-C3)alkoxy;
• and
• R7 and R8 are each independently hydrogen, hydroxy, (C1-C3)alkyl, hydroxy(C1-C3)alkyl, (C1-C3)alkoxy(C1-C3)alkyl, aminocarbonyl-O(C1-C3)alkyl, hydroxycarbonyl(C1-C3)alkoxy(C1-C3)alkyl, (C1-C3)alkylcarbonylamino(C1-C3)alkyl, (C1-C3)alkoxycarbonylamino(C1-C3)alkyl, di(C1-C3)alkylamino(C1-C3)alkyl, di(C1-C3)alkylaminocarbonyl(C1-C3)alkyl, (C1-C3)alkylaminocarbonyl(C1-C3)alkyl, aminocarbonyl(C1-C3)alkyl, aminocarbonyl, mono(C1-C3)alkylamino, di(C1-C3)alkylamino, CO2H, (CH2)1-3COOH, moncyclic heterocyclyl, (C1-C3)alkoxycarbonyl, halophenyl, halophenyl(C1-C3)alkyl, or quinolin-2(1H)one-4yl-methyl;
• or
• R7 and R8, together with the carbon atom to which they are attached, form a 3- to 6-membered cycloalkyl or heterocyclyl.