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US 9,845,307 B2Granted
Nrf2 activating compounds and uses thereof
OwnerMatthew Duncton, Rajinder Singhinventors
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Abstract
Aspects of the present disclosure include compounds that activate Nrf2. Such compounds find use in the treatment of autoimmune and inflammatory diseases and disorders, such as for example psoriasis and multiple sclerosis. Embodiments of the present disclosure also relate to pharmaceutical compositions that include these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
Claims18
A compound of formula (I):
- wherein:
- X1 and X2 are each independently selected from N and CH, wherein at least one of X1 and X2 is N;
- either Y1 is sulfonyl and Y2 is hydrogen, or Y2 is sulfonyl and Y1 is hydrogen;
- and
- each R1 is independently selected from hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, substituted cycloalkyl, heterocyclyl, substituted heterocyclyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl and R15, wherein R15 comprises a linking group and a compound of formula (I);
- or a salt or stereoisomer thereof.
3 more elements
Dependencies are inferred from the claim text.