Cationic lipid
AssigneeKyowa Hakko Kirin Co., Ltd.
InventorsTakeshi Kuboyama, Tomohiro Era, Tomoyuki Naoi
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Abstract
The present invention provides a cationic lipid, which allow nucleic acids to be easily introduced into cells, represented by formula (I) (wherein: R1 and R2 are, the same or different, alkenyl, etc, and X1 and X3 are hydrogen atoms, or are combined together to form a single bond or alkylene, and X3 is absent or is alkyl, etc, Y is absent or anion, a and b are, the same or different, 0 to 3, and L3 is a single bond, etc, R3 is alkyl, etc, L1 and L2 are —O—, —CO—O— or —O—CO—), a composition comprising the cationic lipid and a nucleic acid, and a method for introducing a nucleic acid into a cell by using the composition comprising the cationic lipid and the nucleic acid, and the like.
Claims12
A cationic lipid represented by formula (I):
- wherein:
- R1 and R2 are, the same or different, each linear or branched alkyl, alkenyl or alkynyl having:
- 12 to 24 carbon atoms, or R1 and R2 are combined together to form dialkylmethylene, dialkenylmethylene, dialkynylmethylene or alkylalkenylmethylene;
- X1 and X2 are hydrogen atoms, or combined together to form a single bond or alkylene;
- X3 and Y are absent;
- a and b are, the same or different, 1 to 3;
- L3 is a single bond;
- R3 is a hydrogen atom;
- and
- L1 and L2 are, the same or different, —O— or
Dependencies are inferred from the claim text.