Back to results
US 9,845,303 B2Granted
Process for the preparation of dapagliflozin
AssigneeCadila Healthcare Limited
InventorsSanjay Jagdish Desai, Jayprakash Ajitsingh Parihar, Mahesh Laljibhai Rupapara
Life of this patent
Estimating the term…
Abstract
Dapagliflozin compounds and process for dapagliflozin preparation are described. Pharmaceutical compositions comprising dapagliflozin or solvates of dapagliflozin, for the treatment of diabetes are also described.
Claims15
A Dapagliflozin solvate of general Formula (III),
- wherein X is 1,2-butanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, (S)-1,2-butanediol, (R)-1,2-butanediol, (S)-1,2-pentanediol, (R)-1,2-pentanediol, (S)-1,2-hexanediol, (R)-1,2-hexanediol, (S)-1,2-heptanediol or (R)-1,2-heptanediol, or a hydrate, or a mixture or a hydrate thereof.
A dapagliflozin 1,2-butanediol monohydrate of Formula (II),
A stable amorphous dapagliflozin that does not convert to any other solid form when stored at a temperature of up to about 40° C. and at a relative humidity of about 25% to about 75% for about three months or more.
Dependencies are inferred from the claim text.