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US 9,845,298 B1Granted
5-HT2B antagonists
AssigneeNational Institute of Biological Sciences, Beijing
InventorsNiu Huang, Yu Zhou, Xingyu Lin
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Abstract
The invention provides novel compounds and compositions comprising a 5-HT2B antagonist of formula I: and related methods for treating a person having a disorder characterized by undesirable 5-HT2B receptor signaling, such as migraine, irritable bowel syndrome (IBS), pulmonary arterial hypertension (PAH), fibrosis, hepatocellular cancer, a small intestinal neuroendocrine tumor, cardiovascular disorders, and gastrointestinal (GI) tract disorders.
Claims20
A pharmaceutical composition comprising a compound that is a 5-HT2B antagonist of formula I:
- wherein:
- R1 and R2 are independently H or Me;
- R3 and R4 form cyclohexyl;
- R5 is H;
- R6 is halogen, COR10, COOR10, or CONR10R10, wherein each R10 is independently H or C1-C4 alkyl;
- R7 is H or methyl;
- R8 is H or halogen;
- and
- R9 is H;
- or salt thereof, wherein the salt is a pharmaceutically-acceptable salt, and a pharmaceutically-acceptable excipient, in unit dosage.
7 more elements
Dependencies are inferred from the claim text.