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US 9,845,293 B2Granted
Process for the preparation of eslicarbazepine and eslicarbazepine acetate
AssigneeF.I.S. Fabbrica Italiana Sintetici S.p.A.
InventorsSimone Zaramella, Emiliano Rossi, Ottorino De Lucchi, Siro Serafini
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Abstract
Object of the present invention is an improved process for the preparation of Elsicarbazepine and Eslicarbazepine acetate by means of chiral Ruthenium catalysts.
Drawings
Claims14
A process for the preparation of Eslicarbazepine of formula (II):
- by enantioselective reduction of Oxcarbazepine of formula (III):
- wherein said enantioselective reduction is carried out in presence a chiral catalyst of formula (IV):
- wherein X is a hydrogen atom or a halogen atom;
- R1 is a linear or branched C1-5 alkyl, an unsubstituted aryl, a substituted aryl with a linear or branched C1-5 alkyl group or is a linear or branched C1-5 alkyl-aryl;
- and
- R2 is hydrogen, a linear or branched C1-5 alkyl, linear or branched C1-5 alkoxy group.
3 more elements
Dependencies are inferred from the claim text.