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US 9,845,287 B2Granted
Disubstituted amino acids and methods of preparation and use thereof
AssigneeAileron Therapeutics, Inc.
InventorsKrzysztof Darlak, Noriyuki Kawahata, Sameer Ahmed Athamneh
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Abstract
Provided are crystalline α, α-disubstituted amino acids and their crystalline salts containing a terminal alkene on one of their side chains, as well as optionally crystalline halogenated and deuterated analogs of the α, α-disubstituted amino acids and their salts; methods of making these, and methods of using these.
Claims25
A crystalline composition comprising a crystalline compound of Formula (I):
- wherein:
- R1 is C1-C3 alkyl, C1-C3 deuteroalkyl, or C1-C3 haloalkyl;
- * is a stereocenter;
- n is an integer from 3 to 11;
- R2 is 9-Fluorenylmethoxycarbonyl (Fmoc);
- and
- R3 is —H;
- and wherein the crystalline composition further comprises hexane and chloroform.
5 more elements
The crystalline composition claim of 1, wherein R1 is methyl.
A crystalline compound of Formula (I):
- wherein:
- R1 is C1-C3 alkyl, C1-C3 deuteroalkyl, or C1-C3 haloalkyl;
- * is a stereocenter;
- n is an integer from 3 to 11;
- R2 is 9-Fluorenylmethoxycarbonyl (Fmoc);
- and
- R3 is —H;
- wherein the crystalline compound is obtained by crystallization of a compound of Formula (I) with a solvent comprising hexane and chloroform.
5 more elements
Dependencies are inferred from the claim text.