Supramolecular approach for preparation of size controllable nanoparticles

A self-assembled supramolecular nanoparticle (SNP), comprising:

• a plurality of binding components, each having a plurality of binding regions, wherein the plurality of binding regions comprises β-cyclodextrin;
• a plurality of cores that are suitable to at least provide some mechanical structure to said self-assembled supramolecular nanoparticle, wherein each of said plurality of cores is one of an organic core or an inorganic core, which comprises at least one core binding element adapted to bind to the binding regions to form a first inclusion complex, wherein the core binding element comprises adamantane, and wherein the first inclusion complex is adamantane-β-cyclodextrin;
• and
• a plurality of terminating components, each having a single terminating binding element that binds to remaining binding regions of one of said plurality of binding components by forming a second inclusion complex, wherein the single terminating binding element comprises adamantane, and wherein the second inclusion complex is adamantane-β-cyclodextrin;
• wherein said plurality of cores and said plurality of binding components self assemble when brought into contact to form said self-assembled supramolecular nanoparticle, and
• wherein said plurality of terminating components act to occupy the remaining binding regions of said plurality of binding components, and said plurality of terminating components are present in a sufficient quantity relative to said plurality of binding regions of said plurality of binding components to terminate further binding, thereby forming a discrete particle, and
• wherein the discrete particle is a member of a monodisperse population having a size of at least about 30 nm and less than about 500 nm.