US 9,844,657 B2 · Compositions comprising nanostructures for cell, tissue and artificial organ growth, and methods for making and using same

Abstract

The invention provides articles of manufacture comprising biocompatible nanostructures comprising nanotubes and nanopores for, e.g., organ, tissue and/or cell growth, e.g., for bone, kidney or liver growth, and uses thereof, e.g., for in vitro testing, in vivo implants, including their use in making and using artificial organs, and related therapeutics. The invention provides lock-in nanostructures comprising a plurality of nanopores or nanotubes, wherein the nanopore or nanotube entrance has a smaller diameter or size than the rest (the interior) of the nanopore or nanotube. The invention also provides dual structured biomaterial comprising micro- or macro-pores and nanopores. The invention provides biomaterials having a surface comprising a plurality of enlarged diameter nanopores and/or nanotubes.

Claims28

Dependent claims

A biocompatible vertically aligned nanotube array structure on a biocompatible substrate comprising a laterally separated nanotube arrangement wherein

i) the outer diameter of the nanotube is from about 10-1000 nm;
ii) the inside diameter of the nanotube is at least about 20%-50% of the outer diameter, or at least about 15%, of the outer diameter;
iii) the height of the nanotube is from between about 40-800 nm;
iv) the aspect ratio is less than about 10;
v) the vertical alignment angle is within from about 0-45 degrees off the vertical direction;
and
vi) the lateral spacing between adjacent nanotubes is from about 2-100 nm.

4 more elements

A dual structured biomaterial comprising:

(a) micro- or macro-pores, wherein the micro or macro pores has an average diameter, or equivalent diameter if the pores are not circular, in the range of between about 0.5-1,000 μm, and the entrances of the micro or macro pores have a smaller diameter or size than the rest, or the interior, of the micro or macro pores;
and,
(b) a surface area covered with nanotubes, TiO2 nanotubes, having an average pore diameter in the range of between about 30-600 nm.

A two or a three-dimensional array comprising:

(a) a solid substrate comprising Ti wires, ribbons or rods, or any combination thereof;
and
(b) a plurality of vertically aligned, laterally spaced, nanotubes associated with the substrate, wherein each nanotube comprises a nanopore wherein the outer diameter of each nanotube is about 10-1000 nm;
or about 30-300 nm;
about 60-200 nm and wherein:
(a) the nanopore of each nanotube comprises a diameter of about at least about 20% to 50% of the outer diameter;
(b) the nanopore of each nanotube comprises a diameter of at least about 15% of the outer diameter of the nanotube;
(c) the two or a three-dimensional array of (b), wherein the nanopore of each nanotube comprises a diameter of at least about 20% of the outer diameter of the nanotube;
(d) the two or a three-dimensional array of (c), wherein the nanopore of each nanotube comprises a diameter of at least about 25% of the outer diameter of the nanotube;
(e) the two or a three-dimensional array of (d), wherein the nanopore of each nanotube comprises a diameter of at least about 30% of the outer diameter of the nanotube;
(f) the two or a three-dimensional array of (e), wherein the nanopore of each nanotube comprises a diameter of at least about 35% of the outer diameter of the nanotube;
(g) the two or a three-dimensional array of (f), wherein the nanopore of each nanotube comprises a diameter of at least about 40% of the outer diameter of the nanotube;
or
(h) the two or a three-dimensional array of (g), wherein the nanopore of each nanotube comprises a diameter of at least about 45% of the outer diameter of the nanotube.

11 more elements

Dependencies are inferred from the claim text.

Facts

Application

15/043,382Filed 12 Feb 2016 · continuation

Priority

28 Apr 2005

Published

US 2016/0310718 A127 Oct 2016

Granted

19 Dec 2017

Term ends

Not estimatedThe source records don’t support an estimate.

Classification24 codes

A61M 37/0092
Other apparatus for introducing media into the body ; Percutany, i.e. introducing medicines into the body by diffusion through the skin: using…
A61K 9/0009
Galenical forms characterised by the drug release technique; Application systems commanded by energy: involving or responsive to electricity,…
A61K 9/0024
Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in…
A61K 9/0097
Galenical forms not covered by A61K9/02 - A61K9/7023: medicinal compositions released by microdevices, e.g. microelectromechanical systems [MEMS],…

Family

Application60/676,602Us provisional application · filed 28 Apr 2005

Application60/710,051Us provisional application · filed 22 Aug 2005

Application60/710,245Us provisional application · filed 22 Aug 2005

Application60/773,868Us provisional application · filed 15 Feb 2006

Application60/773,885Us provisional application · filed 15 Feb 2006

PCT/US2006/016471Parent of this division · filed 28 Apr 2006

Application13/858,042Parent of this continuation · filed 6 Apr 2013

US 8,414,908 B2Parent of this division · filed 9 Apr 2013

US 2016/0310718 A1Pre-grant publication · published 27 Oct 2016

US 9,273,277 B2Parent of this continuation

Application11/913,062Parent of this division

Application13/858,042Parent of this division

US 2009/0220561 A1Published application

US 2013/0344600 A1Published application

US 9,844,657 B2This patent

From the US filing history. Foreign family members aren’t listed.

Compositions comprising nanostructures for cell, tissue and artificial organ growth, and methods for making and using same

Life of this patent

Compositions comprising nanostructures for cell, tissue and artificial organ growth, and methods for making and using same

Life of this patent

Abstract

Claims28