Separation material
AssigneeGambro Lundia AB
InventorsMartin Rempfer, Wolfgang Freudemann, Cornelia Winz, Ralf Flieg, Markus Storr, Sandra Homeyer, Torsten Knoer
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Abstract
A separation material includes a matrix that is bound to a saccharide, enabling the separation from a liquid of substances that selectively bind the saccharide. A method for preparing the separation material and a method for separating substances from a liquid that selectively bind a saccharide of the separation material are also described. A device employs the separation material for separating from a liquid substances that selectively bind to the saccharide of the separation material.
Claims19
A separation material of formula (VI) for selective separation of a blood group A determinant and/or a blood group B determinant from blood, blood plasma, or a blood product
- wherein
- saccharide represents a blood group A determinant and/or a blood group B determinant;
- R1 represents, independently of one another, straight- chain or branched C1-C10 alkyl, wherein the alkyl group can be unsubstituted, or substituted with at least one substituent, selected from the group of substituents comprising halogen, alkyl, alkoxy, haloalkyl, cyano, nitro, amino, amidino, hydroxy, thiol, acylamino, alkoxycarbonylamino, haloalkoxycarbonylamino or alkylsulfonylamino;
- Ra represents —H, methyl or ethyl;
- K represents —CO—, —NH— or —CH2—;
- L represents —CH2—, —NH— or —O—;
- Rb represents, independently of one another, straight-chain or branched C1-C10 alkyl such as methyl, ethyl, n- or iso-propyl, n-, iso-, sec- or tert-butyl, n- pentyl, n-hexyl, n-heptyl, n-octyl, n-nonyl or n- decyl, wherein the alkyl group can be unsubstituted, or substituted with at least one suitable substituent, selected from the group of substituents consisting of halogen, alkyl, alkoxy, haloalkyl, cyano, nitro, amino, amidino, hydroxy, thiol, acylamino, alkoxycarbonylamino, haloalkoxycarbonylamino or alkylsulfonylamino;
- F2 represents —NH—, —CH2—, —C(O)—, —N═, —O—, —CH═, —CH(OH)—or CH2—CH(OH)—;
- c and d independently of each other represent 0 or 1;
- M1 represents —NH—, —CH2—, —C(O)—, —N═, —O— or —CH═;
- R2 represents, independently of one another, straight-chain or branched C1-C10 alkyl, wherein the alkyl group can be unsubstituted, or substituted with at least one suitable substituent, selected from the group of substituents consisting of halogen, alkyl, alkoxy, haloalkyl, cyano, nitro, amino, hydroxy, thiol, acylamino, alkoxycarbonylamino, haloalkoxycarbonylamino or alkylsulfonylamino;
- R3 represents, independently of each other, —CO—NH—, —NH—CO—, —CO—NH—NH—, —NH—NH—CO—, —CH═N—NH—, —NH—N═CH—, —N═CH—, —CH═N — or triazolyl,
- r represents 0 or an integer from 1-10;
- w represents —O—, —S—, —CH2— or —NR′—, wherein R′ represents H, or methyl;
- x represents an integer from 1-50.
Dependencies are inferred from the claim text.