Tissue-separating fatty acid adhesion barrier
AssigneeAtrium Medical Corporation
InventorsThomas M. Swanick, Joe Bienkiewicz, Joseph Ferraro, Paul Martakos, Keith M. Faucher, Alicia Dale
Life of this patent
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Abstract
Exemplary embodiments of the present invention provide adhesion barriers having anti-adhesion and tissue fixating properties. The adhesion barriers are formed of fatty acid based films. The fatty acid-based films may be formed from fatty acid-derived biomaterials. The films may be coated with, or may include, tissue fixating materials to create the adhesion barrier. The adhesion barriers are well tolerated by the body, have anti-inflammation properties, fixate, well to tissue, and have a residence time sufficient to prevent post-surgical adhesions.
Claims26
An adhesion barrier implantable in a patient to minimize adhesion formation following surgery, wherein the adhesion barrier comprises:
- an anti-adhesion material having tissue anti-adhesion characteristics, wherein the anti-adhesion material comprises omega-3 fatty acids cross-linked directly to each other, wherein the cross-links include ester bonds, wherein the anti-adhesion material is bioabsorbable;
- and
- a tissue fixating material disposed on a surface of the anti-adhesion material, wherein the tissue fixating material comprises carboxymethylcellulose;
- wherein the anti-adhesion material and the tissue fixating material form the adhesion barrier in such a way that the tissue-separating barrier is non-inflammatory and fixates to tissue, in vivo, for a duration of greater than 10 days.
An adhesion barrier implantable in a patient to minimize adhesion formation following surgery, wherein the adhesion barrier comprises:
- a film derived from a fatty acid-derived biomaterial comprising fish oil;
- and
- a tissue fixating material disposed throughout the film, wherein the tissue fixating material comprises carboxymethylcellulose;
- wherein the film comprises fish oil fatty acids cross-linked directly to each other by an ester bond;
- wherein the film and the tissue fixating material form the tissue-separating barrier so the tissue-separating barrier is non-inflammatory and fixates to tissue, in vivo, for a duration of greater than 10 days, wherein the tissue fixating material comprises a tissue fixating coating surrounding the film and wherein the fatty acid-derived biomaterial reduces inflammation when implanted in a patient.
A method for preparing an adhesion barrier formed of a film having tissue anti-adhesion characteristics and a tissue fixating material, wherein adhesion barrier is non-inflammatory and fixates to tissue, in vivo, for a duration of greater than 10 days, wherein the method comprises the steps of:
- creating the film from fish oil, wherein the film is bioabsorbable and comprises fish oil fatty acids cross-linked directly to each other by an ester bond;
- and
- combining the film with the tissue fixating material to form the adhesion barrier, wherein the tissue fixating material comprises carboxymethylcellulose, and wherein the tissue fixating material is disposed throughout the fatty-acid based film and the film is combined with the tissue fixating material so as to reduce inflammation when the adhesion barrier is implanted in a patient.
An adhesion barrier implantable in a patient to minimize adhesion formation following surgery, wherein the adhesion barrier comprises:
- fatty-acid based particles derived from a fatty acid-derived biomaterial comprising fish oil;
- and
- an aqueous base solution comprising a tissue coherent material, wherein the tissue coherent material comprises carboxymethylcellulose and the fatty-acid based particles comprise fish oil fatty acids cross-linked directly to each other by an ester bond;
- wherein the fatty-acid based particles are mixed with the aqueous base solution to form the adhesion barrier as non-inflammatory and coheres to tissue, in vivo, for a duration of greater than 10 days, wherein the fatty-acid based particles are soaked in a therapeutic agent before being mixed with the aqueous base solution and a mean particle size of the fatty-acid based particles is between about 1 micron and about 50 microns.
An adhesion barrier implantable in a patient to minimize adhesion formation following surgery, wherein the adhesion barrier comprises:
- an emulsion base, wherein the emulsion base comprises an aqueous solution, carboxymethylcellulose, fish oil and particles, wherein the particles are comprised of fish oil fatty acids cross-linked directly to each other by an ester bond, and wherein the tissue-separating barrier is non-inflammatory and fixates to tissue, in vivo, for a duration of greater than 10 days.
Dependencies are inferred from the claim text.