Back to results
US 9,844,607 B2Granted
Immuno imaging agent for use with antibody-drug conjugate therapy
AssigneesSanofi, The Board of Trustees of the Leland Stanford Junior University
InventorsJochen Kruip, Sanjiv S. Gambhir, Susanta K. Sarkar, Mathias Gebauer, Christian Lange, Ingo Focken, Richard Kimura, Arutselvan Natarajan, Ohad Ilovich
Life of this patent
Estimating the term…
Abstract
The invention relates to a companion diagnostic antibody-like binding protein based on the humanized monoclonal antibody, DS6, to be used as diagnostic tool for in vivo detection and quantification of the tumor-associated MUC1-sialoglycotope, CA6.
Claims12
An antibody-like binding protein that specifically binds CA6, wherein the antibody-like binding protein comprises two polypeptides having structures represented by the formulas [I] and [II] below:
- VL1-L1-VL2-CL [I]
- VH1-L2-VH2-CH1 [II]
- wherein:
- VL1 is a DS6-based immunoglobulin light chain variable domain comprising SEQ ID NO:
- 2;
- VL2 is a DS6-based immunoglobulin light chain variable domain comprising SEQ ID NO:
- 2;
- VH1 is a DS6-based immunoglobulin heavy chain variable domain comprising SEQ ID NO:
- 8;
- VH2 is a DS6-based immunoglobulin heavy chain variable domain comprising SEQ ID NO:
- 8;
- CL is an immunoglobulin light chain constant domain;
- CH1 is an immunoglobulin CH1 heavy chain constant domain;
- L1 and L2 are amino acid linkers;
- wherein the polypeptides of formula I and the polypeptides of formula II form a bivalent monospecific tandem immunoglobulin antibody-like binding protein;
- and
- wherein the antibody-like protein further comprises a chelator.
14 more elements
Dependencies are inferred from the claim text.