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AssigneeQueen Mary & Westfield College
InventorsAhuva Nissim, Yuti Chernajovsky, Bjarne Faurholm, David Perrett, Paul Winyard, Christopher Hughes, Stephen Mather, Francesco Dell'Accio
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The present invention provides a composition comprising an antibody or fragment thereof against oxidized Collagen II (CII) in which the antibody or fragment thereof is conjugated to a pharmaceutically active moiety. The invention also provides a composition comprising an antibody or fragment thereof against oxidized Collagen II (Gil) and a detectable label. The invention further provides the use of such compositions in medicine, in particular for the treatment of an arthropathy, and in methods of diagnosis.
A composition comprising an antibody or fragment thereof against oxidised collagen II (CII) in which the antibody or fragment thereof is conjugated to a pharmaceutically active moiety, wherein the antibody or fragment thereof comprises CDR sequences in the variable heavy (VH) chains and variable light (VL) chains as follows:
A composition comprising an antibody or fragment thereof against oxidised collagen II (CII) and a detectable label, wherein the antibody or fragment thereof comprises CDR sequences in the variable heavy (VH) chains and variable light (VL) chains as follows:
Dependencies are inferred from the claim text.