US 9,844,599 B2Granted

Nitric oxide releasing produgs of therapeutic agents

OwnerApparao Satyaminventor

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Abstract

The present invention relates to nitric oxide releasing prodrugs of known drugs or therapeutic agents wherein the drug or therapeutic agents contain at least one carboxylic acid group. The invention also relates to processes for the preparation of these nitric oxide releasing prodrugs, to pharmaceutical compositions containing them and to methods of using these produgs.

Claims6

Dependent claims

A derivative of a therapeutic agent comprising aspirin, naproxen, or chlorambucil, selected from the group consisting of:

or geometrical, stereo-isomers, or pharmaceutical compositions thereof.

Dependencies are inferred from the claim text.

Facts

Application: 14/761,887Filed 17 Jan 2014
Priority: IN 181/MUM/201321 Jan 2013
Published: US 2015/0328323 A119 Nov 2015
Granted: 19 Dec 2017
Term ends: Not estimatedThe source records don’t support an estimate.

Classification25 codes

A61K 31/621
Having the carboxyl group in position 1 esterified, e.g. salsalate: having the hydroxy group in position 2 esterified, e.g. benorylate
A61K 47/542
The modifying agent being an organic compound: carboxylic acids, e.g. a fatty acid or an amino acid
A61K 31/21
Medicinal preparations containing organic active ingredients: esters, e.g. nitroglycerine, selenocyanates
A61K 31/216
Of carboxylic acids: of acids having aromatic rings, e.g. benactizyne, clofibrate

Family

US 2015/0328323 A1Pre-grant publication · published 19 Nov 2015
US 9,844,599 B2This patent

From the US filing history. Foreign family members aren’t listed.

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