Mosaic clade M human immunodeficiency virus type 1 (HIV-1) gag immunogens
AssigneesDuke University, Los Alamos National Security, LLC, Beth Israel Deconess Medical Center, Inc., The UAB Research Foundation
InventorsBette T. Korber, William Fischer, Norman Letvin, Hua-Xin Liao, Barton F. Haynes, Beatrice H. Hahn
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Abstract
The present invention relates, in general, to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to methods of using same. The invention further relates to methods that use a genetic algorithm to create sets of polyvalent antigens suitable for use, for example, in vaccination strategies.
Claims9
A polypeptide or protein comprising any one of the mosaic Gag polypeptide Gag M4.1-4Dmyr selected from the group consisting of SEQ ID Nos:
- 173-176.
Dependencies are inferred from the claim text.