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US 9,844,589 B2Granted
Modified human immunodeficiency virus type 1 (HIV-1) group M consensus envelope glycoproteins capable of inducing broadly reactive T- and B-cell responses
AssigneesDuke University, The University of Alabama Birmingham Research Foundation, Los Alamos National Security, LLC
InventorsBarton F. Haynes, Feng Gao, Bette T. Korber, Beatrice H. Hahn, George M. Shaw, Denise Kothe, Ying Ying Li, Julie Decker, Hua-Xin Liao
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Abstract
The invention relates to HIV-1 envelope polypeptides comprising the consensus envelope of SEQ ID NO: 35, compositions comprising these envelopes and methods for using same.
Claims11
A recombinant protein comprising the sequence of amino acids set forth in FIG. 29A (SEQ ID NO:
- 35).
A recombinant gp120 envelope protein derived from SEQ ID NO:
- 35, wherein the recombinant gp120 envelope protein comprises the consecutive amino acid sequence represented by amino acid numbers 30 to 484 of SEQ ID NO:
- 35.
Dependencies are inferred from the claim text.