Pharmaceutical composition and functional food comprising natural extracts for preventing or treating diabetic complications or angiodema

#This application is a national phase application under 35 U.S.C. §371 of International Patent Application No. PCT/KR2014/000292 filed Jan. 10, 2014, which claims priority to and the benefit of Korean Patent Applications No. 10-2013-0003125, filed Jan. 10, 2013, and No. 10-2013-0050320, filed May 3, 2013. The entire contents of the referenced applications are incorporated herein by reference.

#The present invention relates, in general, to a pharmaceutical composition and a health functional food composition for prevention, treatment or amelioration of diabetic complications or angioedema containing a mixed extract of Hedera helix leaves and Coptis chinensis and, more particularly, to a pharmaceutical composition and a health functional food composition for prevention, treatment or amelioration of diabetic complications or angioedema further containing an extract(s) of Rheum palmatum, Puerariae radix, Ginkgo leaves, Cassiae semen, blueberry, bilberry, raspberry, or grape seeds as an active ingredient, in addition to the mixed extract of Hedera helix leaves and Coptis chinensis.

#Generally, diabetes mellitus is a globally occurring adult disease. Recently, the occurrence rate of diabetes mellitus in Korea has reached 10%, and the global diabetes mellitus population has already passed 240 million. According to a report by the Journal of the American Medical Association (JAMA) in 2009, the number of diabetics globally is expected to grow to 380 million, and among them, about 60% of the diabetes mellitus cases will occur in Asian regions. In particular, the onset of diabetes mellitus has advanced to young adults, and the occurrence of complications has become unavoidable due to extended life expectancy.

#FIG. 1 shows a result of the inhibition of diameter increase of a vitreous body retinal vessel in a zebrafish model by a mixture of a Hedera helix leaf extract and Coptis chinensi extract (COPH).

#FIG. 2 shows (a) a qualitative analysis result, and (b) a quantitative analysis result of the inhibition of retinal vessel damage by COPH, in an STZ-diabetic animal model.

#FIG. 3 shows results of the effect of COPH in lowering the amount of (a) proteinuria, (b) advanced glycation endproducts (AGEs) in urine, and (c) 8-OHdG, in an STZ-diabetic animal model.

#The present invention provides a pharmaceutical composition for prevention or treatment of diabetic complications or angioedema containing a mixed extract of Hedera helix leaves and Coptis chinensis as an active ingredient.

#Additionally, the composition may further contain an extract(s) of Rheum palmatum, Puerariae radix, Ginkgo leaves, Cassiae semen, blueberry, bilberry, raspberry or grape seeds, in addition to the mixed extract of Hedera helix leaves and Coptis chinensis.

#As used herein, the term “a mixed extract of Hedera helix leaves and Coptis chinensis” refers to a mixture between a Hedera helix leaf extract and a Coptis chinensis extract; or an extract prepared by extracting the mixture of Hedera helix leaves and Coptis chinensis.