Pharmaceutical composition for the preparation of infusion solutions of antimicrobial preparations, its production process (variations)

A method of making an injection pharmaceutical composition soluble in water, said method comprising the steps of:

• (a) preparing a powder composition consisting of sodium chloride in a powder form and powdered silica nanoparticles having an average diameter of from 7-40 nm joined into microparticles having a size of less than 100 μm, wherein said sodium chloride and said powdered silica are present in said powder composition in a weight ratio of 4.5:1 to 4.5:5 or 9:1 to 9:5, and further wherein said powder composition has a mass fraction;
• (b) subjecting said powder composition to intensive mechanical impact and abrasive action, so that at least 35% of said silica microparticles are reduced to dimensions not exceeding 5 micrometers, thereby increasing said mass fraction of said powder composition and producing a mechano-chemical activated powder composition;
• c) selecting a single dose of a dry powder of a pharmaceutical agent soluble in water for injection, and dissolving said single dose in 10 ml of water, thereby obtaining a pharmaceutical solution;
• d) mixing said pharmaceutical solution of step (c) with said mechano-chemical activated power composition of step (b), thereby obtaining a suspension;
• e) shaking said suspension for 2-3 minutes to provide an injection pharmaceutical composition;
• and
• f) further dissolving said injection pharmaceutical composition in 50 to 200 ml of a 0.45% or 0.9% aqueous solution of sodium chloride, thereby obtaining a ready to use injection pharmaceutical composition.