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US 9,844,563 B2Granted
Compositions, kits, and methods to induce acquired cytoresistance using stress protein inducers
AssigneeFred Hutchinson Cancer Research Center
InventorsRichard A. Zager, Ali C M Johnson
Life of this patent
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Abstract
The present disclosure provides compositions, kits, and methods to protect organs by inducing acquired cytoresistance without causing injury to the organ. The compositions, kits, and methods utilize heme proteins, iron and/or vitamin B12 and, optionally, agents that impact heme protein metabolism.
Claims14
A method of protecting an organ of a human patient from injury based on a scheduled insult comprising administering to the organ a therapeutically effective amount of (i) iron sucrose;
- and (ii) a protoporphyrin, the therapeutically effective amount being administered before the scheduled insult to the organ occurs, wherein the administering protects the organ from the injury without causing injury to the organ.
Dependencies are inferred from the claim text.