Administration of nicotinamide mononucleotide in the treatment of disease
AssigneeWashington University
InventorsShin-ichiro Imai, Rajendra Apte
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Abstract
Disclosed are methods and compositions related to methods of treating, ameliorating, mitigating, slowing, arresting, preventing or reversing various diseases and conditions, including age-related obesity, age-related increases in blood lipid levels, age-related decreases in insulin sensitivity, age-related decreases in memory function, and age-related changes in eye function such as macular degeneration. The methods comprise administering nicotinamide mononucleotide (NMN) to a subject. In some embodiments, the administration can be oral administration. Also disclosed are pharmaceutical compositions comprising NMN.
Claims18
A method of treating photoreceptor degeneration in a subject, comprising:
- administering to a subject in need of treatment a pharmaceutically effective amount of nicotinamide mononucleotide (NMN) or a salt or prodrug thereof.
A method of improving photoreceptor cell function in a mammalian subject, comprising administering to a subject in need of treatment a pharmaceutically effective amount of nicotinamide mononucleotide (NMN) or a salt or prodrug thereof.
A method of ameliorating age-associated decline in photoreceptor cell function in a subject, comprising administering to a subject in need of treatment a pharmaceutically effective amount of nicotinamide mononucleotide (NMN) or a salt or prodrug thereof.
Dependencies are inferred from the claim text.