Proliposomal testosterone formulations
AssigneesWestern University of Health Sciences, Tesorx Pharma, LLC
InventorsGuru V. Betageri, Ramachandran Thirucote, Veeran Gowda Kadajji
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Abstract
Novel testosterone formulations are disclosed where testosterone is incorporated into a phospholipid/cholesterol system to produce a proliposomal powder dispersion. The proliposomal powder dispersions of the invention may be formulated with pharmaceutically acceptable excipients to form pharmaceutical compositions. Enterically coated oral dosage forms are disclosed as are methods of treatment for testosterone replacement therapy.
Claims17
A proliposomal powder dispersion, consisting essentially of (a) testosterone undecanoate, (b) cholesterol, and (c) at least one phospholipid, wherein (a) and (b) are present in a weight ratio (a):(b) ranging from 1.0:0.05 to 1.0:0.30 and (a), (b) and (c) are present in a weight ratio of (a):((b)+(c)) ranging from 1.0:1.0 and 1.0:2.5.
Dependencies are inferred from the claim text.