Antibody against human HIF hydroxylase
AssigneeOxford University Innovation Limited
InventorsPatrick Henry Maxwell, Christopher William Pugh, Peter John Ratcliffe, Christopher Joseph Schofield
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Abstract
A novel class of hydroxylases is described having the amino acid sequence of SEQ ID NO: 2, 4, 6 and 8, and variants and fragments thereof having HIF hydroxylation activity. The polypeptides of the invention have in particular prolyl hydroxylase activity. An assay method monitors the interaction of the HIF hydroxylase with a substrate. Modulators of HIF hydroxylase are provided for use in the treatment of a condition associated with increased or decreased HIF levels or activity or for the treatment of a condition where it is desirable to modulate HIF levels or activity.
Claims6
An antibody or a fragment thereof capable of specifically binding a polypeptide comprising:
- (a) the amino acid sequence of SEQ ID NO:2 having HIF (hypoxia-inducible factor) hydroxylase activity;
- or
- (b) a variant thereof having at least 80% identity to the amino acid sequence of SEQ ID NO:2 and having HIF hydroxylase activity.
An antibody or a fragment thereof capable of specifically binding a polypeptide comprising:
- (a) the amino acid sequence of SEQ ID NO:6 having HIF hydroxylase activity;
- or
- (b) a variant thereof having at least 80% identity to the amino acid sequence of SEQ ID NO:6 and having HIF hydroxylase activity.
Dependencies are inferred from the claim text.