Hyoscyamine dosage form

A method of alleviating or treating a condition which can be alleviated or treated by administering hyoscyamine, wherein the method comprises administering to a subject in need thereof a pharmaceutical dosage form which comprises at least one of hyoscyamine and a pharmaceutically acceptable salt thereof, the dosage form comprising two or more hyoscyamine formulations, at least one of the formulations being an immediate release formulation and at least one other one of the formulations being a controlled release formulation, and wherein

• (a) the at least one immediate release formulation is capable of providing a hyoscyamine plasma concentration within the therapeutic range for a first period and the at least one controlled release formulation is capable of providing a hyoscyamine plasma concentration within the therapeutic range for a second period, and wherein the dosage form is capable of providing a hyoscyamine plasma concentration within the therapeutic range for a period which is longer than the combined first and second periods;
• or
• (b) the at least one immediate release formulation is capable of releasing the at least one of hyoscyamine and a pharmaceutically acceptable salt thereof for a first period and the at least one controlled release formulation is capable of releasing the at least one of hyoscyamine and a pharmaceutically acceptable salt thereof for a second period, and wherein the first and second periods overlap to provide a hyoscyamine plasma concentration within the therapeutic range during a period within which neither the immediate release formulation by itself nor the controlled release formulation by itself is capable of providing a hyoscyamine plasma concentration within the therapeutic range.