Methods of maintaining and improving muscle function
AssigneeAbbott Laboratories
InventorsSean Garvey, Suzette Pereira, Neile Edens
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Abstract
Methods of decreasing muscle function decline and improving muscle function in a subject are provided. The methods utilize an effective amount of epigallocatechin-3-gallate (EGCg) to increase the level of muscle vascular endothelial growth factor A (VEGF), to decrease myostatin levels, or both, and thereby decrease muscle function decline or improve muscle function. The EGCg may be provided as part of a nutritional composition.
Claims19
A method of decreasing a myostatin level in a subject in need thereof, the method comprising administering epigallocatechin-3-gallate (EGCg) to the subject in need thereof in an amount effective to:
- decrease the myostatin level thereby decreasing muscle function decline, improving muscle function, or both in the subject;
- wherein the EGCg is administered as part of a nutritional composition comprising at least one source of protein, at least one source of carbohydrate, and at least one source of fat;
- and
- wherein the source of protein is selected from the group consisting of whey protein concentrates, whey protein isolates. whey protein hydrolysates, acid caseins, sodium caseinates, calcium caseinates, potassium caseinates, casein hydrolysates, milk protein concentrates, milk protein isolates, milk protein hydrolysates, nonfat dry milk, condensed skim milk, soy protein concentrates, soy protein isolates, soy protein hydrolysates, pea protein concentrates, pea protein isolates, pea protein hydrolysates, collagen proteins, collagen protein isolates, insect proteins. and combinations thereof.
A method of decreasing a myostatin level in a subject in need thereof, the method comprising administering epigallocatechin-3-gallate (EGCg) to the subject in need thereof in an amount effective to:
- decrease the myostatin level thereby decreasing muscle function decline, improving muscle function, or both in the subject;
- wherein the EGCg is administered as part of a nutritional composition;
- and
- wherein the nutritional composition further comprises a branched-chain amino acid selected from the group consisting of leucine, isoleucine, valine, and combinations thereof.
A method of decreasing a myostatin level in a subject in need thereof, the method comprising administering epigallocatechin-3-gallate (EGCg) to the subject in need thereof in an amount effective to:
- decrease the myostatin level thereby decreasing muscle function decline, improving muscle function, or both in the subject;
- wherein the EGCg is administered as part of a nutritional composition;
- and
- wherein the nutritional composition further comprises β-hydroxy-β-methylbutyrate, β-alanine, or both.
A method of decreasing a myostatin level in a subject in need thereof, the method comprising administering epigallocatechin-3-gallate (EGCg) to the subject in need thereof in an amount effective to:
- decrease the myostatin level thereby decreasing muscle function decline, improving muscle function, or both in the subject;
- wherein the EGCg is administered as part of a nutritional composition;
- and
- wherein the nutritional composition is a clear liquid nutritional product having a pH ranging from 2 to 5 and including 0.5 wt % fat or less.
Dependencies are inferred from the claim text.