Method of treating TDP-43 proteinopathies using hexachlorophene
AssigneeUniversity of South Florida
InventorsUmesh K. Jinwal, Diego A. Peralta, Malathi Narayan
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Abstract
A method of treating TDP-43 proteinopathies such as Alzheimer's disease, amyotrophic lateral sclerosis, and fronto-temporal lobar dementia is presented herein. It was found that administering hexachlorophene to cells expressing endogenous TDP-43 or overexpressing wild-type TDP-43 reduced accumulation of TDP-43 in the cells.
Claims12
A method of treating a neurodegenerative disease characterized by accumulation of TDP-43 protein in a patient in need thereof consisting of administering a therapeutically effective amount of hexachlorophene.
A method of decreasing TDP-43 accumulation in cells comprising contacting the cells with a therapeutically effective amount of hexachlorophene.
A method of inhibiting formation of TDP-43 aggregates in cells comprising contacting the cells with a therapeutically effective amount of hexachlorophene.
Dependencies are inferred from the claim text.